Sana Kliniken
Duisburg

Radiologie und Neuroradiologie

Forschung und Publikationen

Innerhalb der Klinik für Radiologie und Neuroradiologie wurde die Sektion Experimentelle Neuroradiologie gebildet.

Die Forschungstätigkeit befasst sich mit Fragestellungen aus dem Gebiet der Interventionellen Neuroradiologie sowie der neurovaskulären Anatomie und Embryologie. Der Fokus liegt eindeutig in der Erforschung und endovaskulären Therapie sämtlicher Gefäßmissbildungen im Kindesalter, von Neugeborenen mit Vena Galeni Malformation bis hin zu Jugendlichen mit Hämangiomen und vaskulären Malformationen. Zudem ist die Behandlung hochkomplexer, intrakranieller Aneurysmen mit sogenanntem Kissing-Y-Stenting ein weiterer Forschungspunkt.

Die Entwicklungs- und Forschungsarbeiten werden unter anderem in einem Forschungslabor der Klinik für Radiologie und Neuroradiologie mithilfe diverser Fluss- und Phantommodelle in vitro durchgeführt. Gefäßmodelle werden zudem auch für Lehr- und Ausbildungszwecke im Rahmen der DeGIR/DGNR voll zertifizierten Ausbildungsstätte (Module: A,B,C,D,E,F) genutzt und bei der Weiterentwicklung und Festung neuer Katheterverfahren genutzt.

Die Anwendung von neu entwickelten Verfahren findet in Zusammenarbeit mit ärztlichen und nicht-ärztlichen Mitarbeitern der Klinik für Radiologie und Neuroradiologie statt; darüber hinaus bestehen interne Kooperationen mit den Abteilungen für Neurologie, Neurochirurgie, Neuropädiatrie und Neonatologie. Externe Kooperationen bestehen mit dem Institut für Diagnostische und Interventionelle Neuroradiologie der Medizinischen Hochschule Hannover (MHH) mit Herrn Prof. Lanfermann, sowie mit der Technischen Werkstatt der MHH. 


Radiologie und Neuroradiologie
Publikationen

  1. Grieb D, Wensing H, Schulz K, Loehr C, Lanfermann H, Schlunz-Hendann M, Boxberg F. First-Line Aspiration Thrombectomy of M2 Occlusions with a Novel Reperfusion Catheter (REDTM 62): Real-World Experience from Two Tertiary Comprehensive Stroke Centers. Neurointervention. 2024 Jul 2. doi: 10.5469/neuroint.2024.00171. Epub ahead of print. PMID: 38946131.https://pubmed.ncbi.nlm.nih.gov/38946131/

  2. Deuschl C, Goertz L, … Schlunz-Hendann M, Grieb D, … Forsting M, Styczen H. Impact of Vaccination Status on Outcome of Patients With COVID-19 and Acute Ischemic Stroke Undergoing Mechanical Thrombectomy. J Am Heart Assoc. 2024 Apr 19:e031816. doi: 10.1161/JAHA.123.031816. Epub ahead of print. PMID: 38639365. https://pubmed.ncbi.nlm.nih.gov/38639365/

  3. Boxberg F, Al-Tibi M, Schulz K, Lanfermann H, Schlunz-Hendann M, Grieb D. Initial Experience with a New Self-Expanding Open-Cell Stent System with Antithrombotic Hydrophilic Polymer Coating (pEGASUS Stent) in the Treatment of Wide-Necked Intracranial Aneurysms. Neurointervention. 2024 Apr 18. doi: 10.5469/neuroint.2024.00066. Epub ahead of print. PMID: 38632689. https://pubmed.ncbi.nlm.nih.gov/38632689/

  4. Schulz K, Grieb D, Boxberg F, Blaeser K, Scholz M, Schlunz-Hendann M. Embolization of an Intracranial Vertebral Artery Aneurysm via the Deep Cervical Artery. J Neurol Surg A Cent Eur Neurosurg. 2024 Feb 12. doi: 10.1055/s-0044-1779473. Epub ahead of print. PMID: 38346710. https://pubmed.ncbi.nlm.nih.gov/38346710/

  5. Ernst M, Jamous A, Bartl M, Riedel CH, Holtmannspötter M, Voit-Höhne H, Grieb D, Schlunz-Hendann M, Fiebig T, Fiorella D, Klisch J, Lobsien D. Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device. Interv Neuroradiol. 2023 Dec 17:15910199231220964. doi: 10.1177/15910199231220964. Epub ahead of print. PMID: 38105527. https://pubmed.ncbi.nlm.nih.gov/38105527/

  6. Brassel F, Schlunz-Hendann M, Scholz M, Lucaciu R, Fan C, Koch V, Grieb D, Brevis Nunez F, Schwarz S, Sommer CM. Neurointerventional Treatment of Vein of Galen Malformation (VGM): A Structured Review with a Proposal for the Comparison of Outcome Quality. Journal of Vascular Diseases. 2023; 2(2): 236-258 https://doi.org/10.3390/jvd2020018

  7. Döring K, Aburub A, Krauss JK, Lang JM, Al-Afif S, Polemikos M, Weissenborn K, Grosse G, Grieb D, Lanfermann H, Götz F, Abu-Fares O. Early clinical experience with the new generation Pipeline Vantage flow diverter in the treatment of unruptured saccular aneurysms using short-term dual antiplatelet therapy. Interv Neuroradiol. 2023 Oct 5:15910199231205047. doi: 10.1177/15910199231205047. Epub ahead of print. PMID: 37796761.https://pubmed.ncbi.nlm.nih.gov/37796761/

  8. Vaassen P, Feldkamp A, Scholz M, Blau T, Dürr NR, Rosenbaum T (2023) A chance to cut is a chance to cure: complete resection of an atypical neurofibroma prevents further progression to malignancy. Childs Nerv Syst. 2023 Jun 21. doi: 10.1007/s00381-023-06029-5. Epub ahead of print..https://pubmed.ncbi.nlm.nih.gov/37344677/

  9. Grieb D, Meila D, Sommer CM, Schulz K, Abu-Fares O, Donnerstag F, Schlunz-Hendann M, Lanfermann H, Boxberg F. Feasibility and safety of ADAPT in acute distal posterior cerebral artery occlusions. Eur J Radiol. 2023 Jun 17;165:110936. doi: 10.1016/j.ejrad.2023.110936. Epub ahead of print. PMID: 37354767.

  10. Schwarz S, Brevis Nuñez F, Dürr NR, Brassel F, Schlunz-Hendann M, Feldkamp A, Rosenbaum T, Felderhoff-Müser U, Schulz K, Dohna-Schwake C, Bruns N. Doppler Ultrasound Flow Reversal in the Superior Sagittal Sinus to Detect Cerebral Venous Congestion in Vein of Galen Malformation. AJNR Am J Neuroradiol. 2023 Jun;44(6):707-715. doi: 10.3174/ajnr.A7891. Epub 2023 May 25. PMID: 37230540; PMCID: PMC10249685.

  11. Grieb D, Greling B, Schulz K, Boxberg F, Melber K, Abu-Fares O, Lanfermann H, Schlunz-Hendann M, Meila D. Endovascular treatment of distal medium vessel occlusions using microcatheter aspiration thrombectomy, Interv Neuroradiol. 2022 Okt. doi: 10.1177/15910199221133470. Epub 2022 Oct 19 PMID: 36259323

  12. Styczen H, Maus V,…Schlunz-Hendann M, Grieb D,…Forsting M, Deuschl C. Mechanical thrombectomy for acute ischemic stroke in COVID-19 patients: multicenter experience in 111 cases. J Neurointerv Surg. 2022 Sep;14(9):858-862. doi: 10.1136/neurintsurg-2022-018723. Epub 2022 Mar 15. PMID: 35292572; PMCID: PMC8931799.
  13. Melber K, Boxberg FW, Schlunz-Hendann M, Brassel F, Grieb DFJ. Long-term results of wide-necked intracranial bifurcation aneurysms treated with stent-assisted coiling using low-profile acandis acclino stents. Interv Neuroradiol. 2022 Aug 18:15910199221121398. doi: 10.1177/15910199221121398. Epub ahead of print. PMID: 35982641
  14. Vaassen P, Dürr NR, Rosenbaum T. Treatment of Plexiform Neurofibromas with MEK Inhibitors: First Results with a New Therapeutic Option. Neuropediatrics. 2022 Feb;53(1):52-60. doi: 10.1055/s-0041-1740549. Epub 2021 Dec 14. PMID: 34905788
  15. Karamani L, Dürr NR, Suchorska B, Scholz M, Brassel F. Axis fracture due to giant cranial AVM. Oxf Med Case Reports. 2021 Aug 13;2021(8):omab075. doi: 10.1093/omcr/omab075. PMID: 34408896; PMCID: PMC8366072
  16. Vaassen P, Dürr N, Röhrig A, Willing R, Rosenbaum T. Trametinib Induces Neurofibroma Shrinkage and Enables Surgery. Neuropediatrics. 2019 Oct;50(5):300-303. doi: 10.1055/s-0039-1691830. Epub 2019 May 29. PMID: 31141829.
  17. Grieb D, Schlunz-Hendann M, Brinjikji W, Melber K, Greling B, Lanfermann H, Brassel F, Meila D. Mechanical thrombectomy of M2 occlusions with distal access catheters using ADAPT. J Neuroradiol 2019 Jul;46(4):231-237. doi: 10.1016/j.neurad.2019.01.096. Epub 2019 Feb 13 (IF: 3,4)
  18. Grieb D, Meila D, Greling B, Jacobs C, Hechtner M, Schlunz-Hendann M, Brassel F. Craniofacial venous malformations treated by percutaneous sclerotherapy using Polidocanol – a single center experience. Acta Radiol. 2019 May;60(5):593-601. doi: 10.1177/0284185118795326 Epub 2018 Aug 15 (IF: 1,9)
  19. Alves CAPF, Goncalves FG, Grieb D, Lucato LT, Goldstein AC, Zuccoli G. Neuroimaging of Mitochondrial Cytopathies. Top Magn Reson Imaging. 2018 Aug;27(4):219-240. (IF: 2,1)
  20. Winkler O, Brinjikji W, Lanfermann H, Brassel F, Meila D. Anatomy of the deep venous system in vein of Galen malformation and its changes after endovascular treatment depicted by magnetic resonance venography. J Neurointerv Surg. 2019 Jan;11(1):84-89. doi: 10.1136/neurintsurg-2018-013789. Epub 2018 May 24. PMID: 29794159. (IF: 3,78)
  21. Dürr NR, Brinjikji W, Pohrt A, Lanfermann H, Brassel F, Meila D. Non-enhanced MR imaging for preinterventional assessment of the angioarchitecture in vein of Galen malformations. J Neurointerv Surg. 2018 Oct;10(10):999-1004. doi: 10.1136/neurintsurg-2017-013611. Epub 2018 Feb 7. PMID: 29436506.
  22. Meila D, Schmidt C, Melber K, Grieb D, Jacobs C, Jacobs C, Lanfermann H, Brassel F (2017). Delayed and incomplete treatment may result in dural fistula development in children with Vein of Galen malformation. Interv Neuroradiol. 2018 Feb;24(1):82-87. doi: 10.1177/1591019917741755. Epub 2017 Nov 10. (IF: 0,74)
  23. Melber K, Meila D, Draheim P, Grieb D, Greling B, Schlunz-Hendann M, Brassel F (2016). Vascular angular remodeling by kissing-Y stenting in wide necked intracranial bifurcation aneurysms. J Neurointerv Surg. 2017 Dec;9(12):1233-1237. doi: 10.1136/neurintsurg-2016-012858. Epub 2016 Dec 5. (IF: 3,55)
  24. Meila D, Grieb D, Greling B, Melber K, Jacobs C, Hechtner M, Schmitz T, Schlunz-Hendann M, Lanfermann H, Brassel F (2016). Endovascular treatment of head and neck arteriovenous malformations: long-term angiographic and quality of life results. J Neurointerv Surg. 2017 Sep;9(9):860-866. doi: 10.1136/neurintsurg-2016-012570. Epub 2016 Aug 26. (IF: 3,55)
  25. Brassel F, Grieb D, Meila D, Schlunz-Hendann M, Greling B, Melber K (2016). Endovascular treatment of complex intracranial aneurysms using Acandis Acclino stents. J Neurointerv Surg. 2017 Sep;9(9):854-859. doi: 10.1136/neurintsurg-2016-012571. Epub 2016 Aug 24. (IF: 3,55)
  26. Meila D, Melber K, Grieb D, Jacobs C, Lanfermann H, Brassel F (2017). Fistulous-type vein of Galen malformation phantom model for endovascular training and research. J Neurointerv Surg. 2017 Sep;9(9):880-886. doi: 10.1136/neurintsurg-2016-012568. Epub 2016 Aug 10. (IF: 3,55)
  27. Meila D, Grieb D, Melber K, Jacobs C, Maslehaty H, Petridis A, El Habony R, Lanfermann H, Scholz M, Brassel F (2016). Hydrocephalus in vein of Galen malformation: etiologies and therapeutic management implications. Acta Neurochir (Wien). 2016 Jul;158(7):1279-84. doi: 10.1007/s00701-016-2836-y. Epub 2016 May 13. (IF: 1,88)
  28. Brassel F, Meila D, Schlunz-Hendann M. Interventional treatment in AVM. In: Mattassi R, Loose DA, Vaghi M, editors. Hemangiomas and Vascular Malformations: An Atlas of Diagnosis and Treatment. Milano: Springer; 2015. pp. 255-261.
  29. Brassel F, Meila D (2015). Evolution of Embolic Agents in Interventional Neuroradiology. Clin Neuroradiol, 2015 Jun 18. [Epub ahead of print] (IF: 2,25)
  30. Brassel F, Melber K, Schlunz-Hendann M, Meila D (2015). Kissing-Y stenting for endovascular treatment of complex wide-necked bifurcation aneurysms using Acandis Acclino stents: results and literature review. J Neurointervent Surg 2015 May 18. doi: 10.1136/neurintsurg-2015-011691. [Epub ahead of print] (IF: 2,774)
  31. Petridis AK, Thissen J, Brassel F, Meila D, Scholz M (2015). Perspectives in Meningioma Treatment. J Neurol Disord 3:223.
  32. Seidel DU, Remmert S, Brassel F, Schlunz-Hendann M, Meila D (2014). Superselective microcoil embolization in severe intractable epistaxis: an analysis of 12 consecutive cases from an otorhinolaryngologic and interventional neuroradiologic point of view. Eur Arch Otorhinolaryngol 2014 Dec 11 [Epub ahead of print] (IF: 1,545)
  33. Paramasivam S, Niimi Y, Meila D, Berenstein A (2014). Dural arteriovenous shunt development in patients with vein of galen malformation. Intervent Neuroradiol, 20(6): 78190. (IF: 0,78)
  34. Meila D, Lissek K, Jacobs C, Lanfermann H, Brassel F, Feldkamp A (2015). Cranial Doppler ultrasound in Vein of Galen Malformation. Neuroradiology, 57: 211-19. (IF: 2,485)
  35. Meila D, Saliou G, Krings T (2015). Subcallosal artery stroke: Infarction of the fornix and the genu of the corpus callosum. The importance of the anterior communicating artery complex. Case series and review of the literature. Neuroradiology, 57: 41-7. (IF: 2,485)
  36. Grieb D, Feldkamp A, Lang T, Melter M, Stroszczynski C, Brassel F, Meila D (2014). Caroli disease associated with Vein of Galen Malformation in a male child. Pediatrics, 134(1): e284e288. (IF: 5,473)
  37. Maslehaty H, Ngando H, Meila D, Brassel F, Scholz M, Petridis AK (2013). Estimated low risk of rupture of small-sized unruptured intracranial aneurysms (UIAs) in relation to intracranial aneurysms in patients with subarachnoid haemorrhage. Acta Neurochir, 155(6): 1095-100. (IF: 1,766)
  38. Wetter A, Shin M, Meila D, Brassel F, Schlunz-Hendann M (2013). Treatment of Middle Cerebral Artery Occlusion and Internal Carotid Artery Dissection with Combined Mechanical Thrombectomy and Stenting of the Internal Carotid Artery. The Neuroradiology Journal, 26: 84-88.
  39. Wetter A, Kuepeli G, Meila D, Brassel F, Nacimiento W (2013). CLIPPERS syndrome in a patient with a fluctuating cerebellar syndrome. Neurographics, 3: 11-13.
  40. Meila D, Tysiac M, Brassel F (2013). Re: Variations in the origin of the vertebral artery and its level of entry into the transverse foramen diagnosed by CT angiography. Neuroradiology; 55(5):649. (IF: 2,485)
  41. Meila D, Tysiac M, Petersen M, Theisen O, Wetter A, Mangold A, Schlunz-Hendann M, Papke K, Brassel F, Berenstein A (2012). Origin and course of the extracranial Vertebral Artery – CTA findings, association with vascular lesions and embryologic considerations. Clin Neuroradiol, 22(4): 327-33. (IF: 2,25)
  42. Meila D, Wetter A, Brassel F, Nacimiento W (2012). Intermittent Hypoglossal Nerve Palsy Caused by a Calcified Persistent Hypoglossal Artery: An Uncommon Neurovascular Compression Syndrome. Journal of Neurol Sci, 323(1-2): 248-9. (IF: 2,474)
  43. Meila D, Paramasivam S, Niimi Y, Brassel F, Berenstein A (2012). The Persistent Primitive Marginal Sinus - Observations in children with Vein of Galen Malformation. Neuroradiology, 54(12): 1375-9. (IF: 2,485)
  44. Wetter A, Schlunz-Hendann M, Meila D, Rohde D, Brassel F (2012). Endovascular treatment of a renal arteriovenous malformation with onyx. Cardiovasc Intervent Radiol, 35(1): 211-4. (IF: 2,071)
  45. Emmel M, Bennink G, Meila D, Brassel F (2012). Coarctation of the aorta and vein of Galen malformation - treatment considerations in a severely compromised patient. Cardiol Young, 22(5): 596-9. (IF: 0,835)
  46. Meila D, Hannak R, Feldkamp A, Schlunz-Hendann M, Mangold A, Jacobs C, Papke K, Brassel F (2012). Vein of Galen aneurysmal malformation: combined transvenous and transarterial method using a "kissing microcatheter technique". Neuroradiology, 54(1): 51-9. (IF: 2,485)
  47. Kurre W, Brassel F, Brüning R, Buhk J, Eckert B, Horner S, Knauth M, Liebig T, Maskova J, Mucha D, Sychra V, Sitzer M, Sonnberger M, Tietke M, Trenkler J, Turowski B, Berkefeld J; INTRASTENT study group (2012). Complication rates using balloon-expandable and selfexpanding stents for the treatment of intracranial atherosclerotic stenoses: analysis of the INTRASTENT multicentric registry. Neuroradiology, 54(1): 43-50. (IF: 2,485)
  48. Meila D, Papke K, Schlunz-Hendann M, Mangold A, Jacobs C, Brassel F (2011). Bilateral persistent trigeminal arteries, one of them ending in the posterior inferior cerebellar artery: case report and review of the literature. Clin Neuroradiol, 21(2): 95-9. (IF: 2,25)
  49. Kurre W, Berkefeld J, Brassel F, Brüning R, Eckert B, Kamek S, Klein GE, Knauth M, Liebig T, Maskova J, Mucha D, Neumann-Haefelin T, Pilgram-Pastor S, Sitzer M, Sonnberger M, Tietke M, Trenkler J, Turowski B; INTRASTENT Study Group (2010). In-hospital complication rates after stent treatment of 388 symptomatic intracranial stenoses: results from the INTRASTENT multicentric registry. Stroke, 41(3): 494-8. (IF: 5,723)
  50. Brassel F, Meila D, Papke K (2011). Vascular interventions in the head and neck region. Part 2: Procedures for vessel occlusion. Radiologe, 51(6): 519-33. (IF: 0,425)
  51. Papke K, Meila D, Brassel F (2011). Vascular interventions in the head and neck region. Part 1: Recanalization procedures. Radiologe, 51(3): 223-33; quiz 234-6. (IF: 0,425)